MV Hondius departs Ushuaia, Argentina
147 passengers and crew from 23 countries begin the South Atlantic expedition cruise. The first case is believed to have been exposed to rodents during land activities in the Southern Cone.
The first documented hantavirus outbreak aboard a vessel. Andes virus spread person-to-person among passengers and crew of the MV Hondius in the South Atlantic — the largest known cluster of human-to-human Andes virus transmission.
Last updated: 5/21/26 UTC
As of WHO DON601 · 13 May 2026
In late April 2026, a cluster of Andes virus (hantavirus) cases emerged among passengers and crew of the MV Hondius, a Dutch-flagged expedition cruise ship operating in the South Atlantic near Patagonia. The working hypothesis is that the first case acquired the infection on land — likely during birdwatching activities in Argentina or Chile — before boarding the ship.
Once aboard, the virus spread person-to-person in the ship's enclosed environment. Close living quarters, shared indoor spaces, and prolonged interpersonal contact all facilitated transmission. Genetic sequencing confirmed the outbreak arose from a single zoonotic spillover event, with near-identical viral sequences across all cases.
On May 2, 2026, WHO received notification from the UK's IHR National Focal Point. By May 13, WHO had issued three Disease Outbreak News reports (DON599, DON600, DON601). The ship finally docked in Tenerife, Spain on May 10, where 147 passengers and crew from 23 countries were repatriated via specially arranged non-commercial flights. WHO Director-General Dr. Tedros Adhanom Ghebreyesus personally travelled to the Canary Islands on May 9 to coordinate the response.
As of May 16, a Canadian passenger from Yukon tested presumptive positive after returning home — bringing the total to 11 cases. All confirmed cases are Andes virus (ANDV) infection. Three people have died, with a case fatality ratio of 27%.
The ship departed Ushuaia, Argentina on April 1, 2026. Key events occurred at multiple stops across the South Atlantic before docking in Tenerife, Spain on May 10.
Ship departs. First case likely exposed to rodents during birdwatching activities on land.
First passenger dies aboard the ship.
Wife of deceased passenger medically evacuated to South Africa.
Second passenger dies. Third sick passenger evacuated from ship.
Third passenger dies aboard. WHO notified by UK IHR National Focal Point.
Ship docks. WHO & ECDC experts board. Dutch medical team joins.
Ship arrives. Disembarkation begins. 147 passengers & crew from 23 countries repatriated via special flights.
Ship sails to Netherlands with 25 remaining crew under medical monitoring.
147 passengers and crew from 23 countries begin the South Atlantic expedition cruise. The first case is believed to have been exposed to rodents during land activities in the Southern Cone.
A passenger dies aboard the MV Hondius. The cause is not yet identified as hantavirus at this stage.
The wife of the deceased passenger is medically evacuated from Saint Helena (UK territory) to South Africa for treatment.
A second passenger dies in Johannesburg, South Africa. A third critically ill passenger is evacuated from the ship.
A third passenger dies aboard the ship. WHO receives notification from the UK IHR National Focal Point regarding a cluster of severe acute respiratory illness including two deaths and one critically ill passenger.
WHO publishes the first formal Disease Outbreak News report on the multi-country hantavirus cluster linked to cruise ship travel. Seven cases (2 confirmed, 5 suspected) including three deaths.
WHO and ECDC experts board the ship. Two Dutch medical doctors join to conduct health monitoring. International contact tracing begins.
CDC confirms 8 cases including 3 deaths. Andes virus confirmed as the causative strain. 41 people in the US being monitored. Risk to the American public remains extremely low.
Second WHO report confirms Andes virus. Eight cases including three deaths. International contact tracing ongoing across multiple countries.
Dr. Tedros Adhanom Ghebreyesus travels to Tenerife to meet with national authorities and coordinate the international response. He meets with the Prime Minister of Spain on May 12.
The MV Hondius arrives in the Canary Islands. Passengers and crew are repatriated from Tenerife to their home countries via specially arranged non-commercial flights. WHO supports the disembarkation process.
11 total cases (8 confirmed, 2 probable, 1 inconclusive), 3 deaths. Two additional confirmed cases from France and Spain since the previous report. CFR 27%. Global risk assessed as LOW.
A passenger from Yukon, Canada — one of four Canadians isolating on Vancouver Island — tests presumptive positive. The case brings the total to 11 infections. BC health officer confirms no contact with the public since arrival.
Passengers from 23 countries were aboard the MV Hondius. Confirmed and probable cases have been reported in at least 7 countries.
First to notify WHO via IHR channels
Ship flag state; crew monitoring ongoing
Case became symptomatic during repatriation
Tested positive upon arrival; currently asymptomatic
Presumptive positive in Yukon; 6 Canadians total on ship
One inconclusive result; 41 people under monitoring
Two passengers died in Johannesburg
Likely source of initial zoonotic exposure
This is the first documented hantavirus outbreak to occur on a cruise ship. The enclosed environment, shared spaces, and prolonged close contact among passengers and crew created conditions that facilitated person-to-person transmission.
All other hantavirus strains — including Sin Nombre virus (the most common in the US) — require direct contact with infected rodent excreta. Andes virus is the sole exception, capable of spreading between humans through close and prolonged contact.
The MV Hondius cluster is the largest documented outbreak of person-to-person Andes virus transmission. WHO confirmed transmission occurred through close contact between passengers and crew, not through rodent exposure.
The average age of passengers aboard was 65 years old. Hantavirus Pulmonary Syndrome has a case fatality rate of up to 50%, with higher mortality among elderly individuals and those with comorbidities.
With passengers from 23 countries, the outbreak required unprecedented international coordination. WHO activated three-level coordination, deployed experts to the ship, and supported repatriation via specially arranged flights.
Based on CDC's official FAQ — Andes Virus Outbreak on a Cruise Ship (May 16, 2026)
No. CDC, WHO, and public health experts agree the risk of a pandemic from this outbreak is extremely low. Andes virus has demonstrated limited human-to-human transmission, typically requiring prolonged close contact. The outbreak is geographically contained, and all known contacts are being monitored. Dr. Bonnie Henry (BC Health Officer) stated: 'Hantavirus is a very different virus than COVID, influenza, or measles — it does not have pandemic potential.'
The working hypothesis is that the first case was exposed to infected rodents during land activities (likely birdwatching) in Argentina or Chile before boarding. Once aboard, Andes virus spread person-to-person through close and prolonged contact in the ship's enclosed environment — shared cabins, dining areas, and common spaces. Genetic sequencing confirmed a single source event with near-identical viral sequences across all cases.
As of May 16, 2026, there are 11 total cases: 8 laboratory-confirmed for Andes virus (ANDV), 2 probable, and 1 inconclusive. Three people have died, giving a case fatality ratio of 27%. All cases were passengers aboard the MV Hondius. No crew members have been confirmed positive.
WHO recommends 42 days of active monitoring and home or facility quarantine for high-risk contacts following their last exposure. This is based on the maximum incubation period of Andes virus (up to 8 weeks) plus a safety margin. High-risk contacts include those who shared enclosed spaces, had direct physical contact, or were exposed to a confirmed case's body fluids. Low-risk contacts should self-monitor and seek medical evaluation if symptoms develop.
WHO advises against travel for high-risk contacts during the 42-day monitoring period. Passengers who have been repatriated are being monitored by local health authorities in their home countries. WHO does not recommend any travel or trade restrictions for the general public beyond the movement restrictions for identified high-risk contacts.
Yes, for the general public. WHO states that most routine tourism activities carry little or no risk of exposure to rodents or their excreta. The MV Hondius outbreak was an exceptional event linked to specific land-based exposure in a hantavirus-endemic region (Patagonia). WHO does not recommend any changes to routine activities for people not connected to this outbreak.
Passengers from 23 countries were aboard the MV Hondius. Confirmed or probable cases have been reported in the UK, Netherlands, France, Spain, and Canada. One inconclusive case is in the US. Two passengers died in South Africa. The initial zoonotic exposure is believed to have occurred in Argentina or Chile.
Symptoms of Andes virus (Hantavirus Pulmonary Syndrome) typically appear 1–8 weeks after exposure. Early symptoms include fever, fatigue, muscle aches, headache, dizziness, and gastrointestinal symptoms (nausea, vomiting, diarrhea). Late symptoms include sudden shortness of breath and respiratory distress as the lungs fill with fluid. Seek immediate medical care if you were on the MV Hondius and develop any of these symptoms.
CDC issued a Health Alert Network notice (HAN00528) and is monitoring 41 people in the US. WHO activated three-level coordination, deployed experts to the ship, published three Disease Outbreak News reports, and developed specific technical guidance for contact management and disembarkation. WHO Director-General Dr. Tedros personally travelled to the Canary Islands to coordinate the response.
11 cases (8 confirmed, 2 probable, 1 inconclusive), 3 deaths. CFR 27%. Two additional confirmed cases from France and Spain. Global risk: LOW.
Read full statement ↗CDC Health Alert Network notice. Andes virus confirmed. Risk to the American public remains extremely low. 41 people in the US being monitored.
Read full statement ↗Andes virus confirmed as causative strain. Eight cases including three deaths. International contact tracing ongoing.
Read full statement ↗Initial WHO Disease Outbreak News on severe respiratory illness cases aboard MV Hondius. Seven cases (2 confirmed, 5 suspected) including three deaths.
Read full statement ↗CDC's official FAQ covering Andes virus, outbreak risk, passenger guidance, and the 42-day monitoring period.
Read full statement ↗Andes virus (ANDV) is a type of hantavirus endemic to South America, primarily Argentina and Chile. It is the only hantavirus known to spread person-to-person — a property that makes the MV Hondius outbreak uniquely significant. All other hantavirus strains require direct contact with infected rodent excreta.